Samantha Who

Samantha Who is an American sitcom that aired on ABC from September 25, 2007 to TBA. The series had a total of 48 episodes.

Plot
The show centered on Samantha Newly (Christina Applegate), a 30-year-old vice president of a real estate firm who develops retrograde amnesia after a hit and run accident. After awakening, she progressively realizes to her dismay that she had been selfish and unlikable before her accident, and therefore sets out to make amends and become a better daughter to her somewhat dysfunctional parents, Howard (Kevin Dunn) and Regina (Jean Smart), a better friend to self-centered Andrea (Jennifer Esposito), and needy but well-meaning Dena (Melissa McCarthy), and a better on-again, off-again girlfriend to her roommate and ex-boyfriend, Todd (Barry Watson). Wryly observing her transformation from "Old Sam" to "New Sam" is Samantha's bemused doorman, Frank (Tim Russ). The show centered on Samantha Newly (Christina Applegate), a 30-year-old vice president of a real estate firm who develops retrograde amnesia after a hit and run accident. After awakening, she progressively realizes to her dismay that she had been selfish and unlikable before her accident, and therefore sets out to make amends and become a better daughter to her somewhat dysfunctional parents, Howard (Kevin Dunn) and Regina (Jean Smart), a better friend to self-centered Andrea (Jennifer Esposito), and needy but well-meaning Dena (Melissa McCarthy), and a better on-again, off-again girlfriend to her roommate and ex-boyfriend, Todd (Barry Watson).

Cast

 * Christina Applegate as Samantha "Sam" Newly
 * Jennifer Esposito as Andrea Belladonna
 * Kevin Dunn as Howard Newly
 * Melissa McCarthy as Dena
 * Tim Russ as Frank
 * Barry Watson as Todd Deepler
 * Jean Smart as Regina Newly